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KMID : 0369919950100010037
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Journal of Pharmaceutical Sciences (C.B.N.)
1995 Volume.10 No. 1 p.37 ~ p.48
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Antimicrobial Activity of Natural Rutin Alone and in Combination with Some Antibiotics
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임교환
어성국/김영소/이종길/한성순
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Abstract
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Abstract:
@EN As par of our search for less toxic antimicrobial agents from natural resources, rutin was isolated from Sophora japonica. Antimicrobial activity of rutin was tested in vitro against Gram positive and Gram negative bacteria by serial broth
dilution
method, and the antimicrobial activity was expressed by minimal inhibitory concentration (MIC). Among sixteen kinds of bacteria tested, the antimicrobial activity of rutin was the most potent against Micrococcus luteus and Mycobacterium smegmatis
showing MIC of 500㎍/ml respectively. to investigate the effect of antimicrobial combinations of rutin with four kinds of antibiotics(ampicillin, cefazolin, oxytetracycline and chloramphenicol), the fractional inhibitor concentration index (FICI)
was
determined by checkerboard assay for each strain. The antimicrobial combinations of rutin with four kinds of antibiotics resulted in additivity in four instances, but no antagonism was observed.
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KEYWORD
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